556 papers
This study reveals that epithelial lumen formation is initiated by the bulk delivery of preassembled, microvilli-rich vacuolar apical compartments (VACs) to the apical membrane initiation site, a process coordinated by the Crumbs complex protein PatJ to ensure rapid and efficient lumenogenesis.
This study demonstrates that the selective YEATS-domain inhibitor SR-0813 enhances neuronal stress resilience and ameliorates ALS phenotypes by attenuating PERK-ISR signaling, revealing ENL/AF9 as context-dependent modulators of stress responses that offer a promising therapeutic strategy for specific neurodegenerative conditions.
This study demonstrates that the *C. elegans* Doublecortin-domain protein ZYG-8 ensures accurate mitotic spindle orientation during zygote division by stiffening microtubules to optimize cortical pushing forces, a mechanism whose disruption leads to spindle mispositioning and which may offer insights into cancer-related cell division defects.
This study demonstrates that Schwann cell dysfunction impairs diabetic wound healing by disrupting the injury-induced response, but therapeutic administration of the Schwann cell-derived factor oncostatin M (OSM) can partially rescue this pathology by enhancing epidermal proliferation, angiogenesis, and nerve regeneration.
This study identifies nuclear export as a critical regulator of TDP-43 phase transitions, demonstrating that inhibiting nuclear export promotes a protective liquid-liquid phase separation state within the nucleus, thereby preventing pathogenic cytoplasmic aggregation associated with ALS.
This study demonstrates that in *Dictyostelium discoideum*, the loss of Copine D leads to increased Ras activation, resulting in enhanced proliferation, precocious development, larger fruiting bodies, reduced cell adhesion, and smaller contractile vacuoles, thereby establishing Copine D as a nonredundant regulator of Ras signaling and diverse cellular processes.
This study presents the first comprehensive proteomic map of novel post-translational modifications on alpha- and beta-tubulin in *Trypanosoma cruzi*, revealing a complex "tubulin code" with multiple previously unreported modifications located in solvent-exposed regions that likely regulate the parasite's specialized microtubule structures.
This study reveals that under thermal or metabolic stress, endoplasmic reticulum membranes undergo a large-scale phase transition into rigid, multilamellar "rods" driven by saturated lipid demixing and the exclusion of tubulating proteins, thereby serving as a homeoviscous mechanism to preserve organelle function.
This study reveals that the nuclear receptor CAR maintains hepatocyte ploidy by directly transactivating the RRM2 gene to drive de novo dNTP synthesis and DNA replication, thereby preventing a shift toward diploid hepatocytes.
This study reveals that the lipid kinase PIKfyve regulates endoplasmic reticulum (ER) dynamics and morphology by balancing phosphoinositides at ER-lysosome contact sites, thereby preventing lysosomal clustering that arrests ER hitchhiking and excessive protrudin tethering that distorts ER structure.
This study demonstrates that mammalian epidermal stem cells maintain their proliferative capacity and skin barrier function across both neonatal and adult stages despite significant fibroblast depletion, revealing a robust compensatory mechanism that ensures tissue resilience even when basement membrane mechanics are altered.
This study reveals that cellular adaptability is an evolved physiological architecture shaped by selection history, demonstrating that long-term osmotic stress in yeast reorders a pre-existing hierarchical stress response mechanism, ultimately enhancing tolerance to specific conditions while compromising the cell's ability to integrate diverse environmental cues.
This study demonstrates that the {gamma}-Tubulin Ring Complex ({gamma}-TuRC) is essential for both initiating mitotic spindle assembly and maintaining spindle integrity by acting as a stabilizing minus-end cap, as its rapid depletion causes spindle collapse that can be rescued by inhibiting the depolymerizing kinesin KIF2A.
The human microprotein ZNF706 acts as an RNA chaperone that antagonizes pathological G-quadruplex-driven RNA aggregation in C9orf72 repeat expansions by melting stable structures to promote dynamic condensates and enhance the clearance of toxic dipeptide repeat proteins, offering a potential regulatory mechanism for neurodegenerative diseases like ALS and FTD.
This study demonstrates that the concave topography of epidermal rete ridges acts as a critical physical determinant of epidermal stem cell identity by promoting differentiation through specific chromatin and transcriptional changes, suggesting that the age-related flattening of these ridges contributes to skin aging by disrupting stem cell homeostasis.
This study demonstrates that manipulating ionic concentrations to regulate sodium-calcium cross-talk via NCX and IP3R mechanisms induces synchronized calcium oscillations in endothelial cells, thereby offering a controllable method to stimulate angiogenic signaling and tissue regeneration.
This study presents a clinically compliant, optimized ex vivo expansion protocol for mobilized peripheral blood hematopoietic stem cells that maintains stemness and transduction efficiency, as validated by single-cell sequencing and clonal tracking, paving the way for a gene therapy trial in autosomal recessive osteopetrosis.
Using microneedle manipulation, this study reveals that mammalian anaphase midzone bundles are mechanically coupled both locally and globally via a PRC1-dependent mechanism, allowing the spindle to function as a single mechanical unit that resists force over short timescales while remodeling over longer periods to ensure robust chromosome segregation.
This paper proposes a physical theory of epigenetic memory based on a spreading-writing-erasing model that explains how chromatin compartmentalization balances stability and plasticity, while predicting that noise in histone segregation and rapid proliferation enhance reprogramming efficiency and that chromatin reorganization drives cellular senescence.
This study identifies PES-8 as a critical regulator of cytoskeletal organization and calcium-mediated contractility in the *C. elegans* spermatheca, where its absence disrupts actomyosin alignment, junction integrity, and oocyte transit.