414 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
Using saturation mutagenesis in human induced pluripotent cells and cardiomyocytes, this study reveals that LMNA mutations causing cardiomyopathy uniquely trigger profound protein loss and cellular toxicity in heart cells due to lamin polymer assembly defects, thereby explaining the tissue-specific vulnerability of cardiomyocytes in laminopathies.
The paper introduces SPaCe-MC, a spatially constrained Monte Carlo permutation test that reveals a conserved local diffusion constraint near stress granules across diverse stress conditions, overcoming the limitations of traditional cell-wide average analyses in heterogeneous intracellular environments.
This study reveals the evolutionary plasticity of the nuclear pore complex in *Entamoeba histolytica* by identifying a mix of conserved and lineage-specific nucleoporins, including a remodeled EhNup53-like protein, through proteomic and structural analyses.
This study demonstrates that focal calcium transients at cytoneme contact sites stabilize cell-cell adhesion via E-cadherin in a positive feedback loop with Wnt signaling, thereby facilitating efficient ligand transfer and amplifying canonical Wnt/β-catenin pathway activation.
This study utilizes a large-scale yeast two-hybrid approach coupled with high-throughput sequencing to map the nucleotide-dependent interactomes of major mammalian Rab GTPases, revealing an expanded repertoire of GTP-specific effectors and identifying the RGS domains of Snx13 and Snx14 as novel Rab-binding modules that link ER-localized proteins to specific endosomal compartments.
This study utilizes correlative light and electron microscopy (CLEM) to reveal the native ultrastructural architecture of the human inactive X chromosome, demonstrating that while its heterochromatin domains are larger than autosomal regions, they exhibit similar chromatin density and a distinct interchromatin compartment network.
This study establishes Concanavalin A combined with expansion microscopy as a universal, antibody-free tool for visualizing nuclear envelope integrity across diverse eukaryotes, revealing novel mitotic strategies and supporting the hypothesis that multinucleated life cycles favor closed or intermediate mitosis to protect chromosomes.
This study establishes two viable cryopreservation strategies and identifies an optimal GMP-compliant freezing medium to enable the standardized biobanking, scalable distribution, and broader research application of primary fetal epithelial organoids derived from cryopreserved human amniotic fluid cells.
This study reveals that adaptor proteins spatially constrain and seed the self-assembly of the yeast protein Pan1 into biomolecular condensates, which are essential for organizing the late-stage clathrin-mediated endocytic network.
By integrating single-cell transcriptomics with intravital imaging, this study identifies a distinct intermediate transcriptional state preceding Langerhans cell migration and reveals that wound-derived C3 from fibroblasts regulates their accumulation at injury sites.